製備作為醫藥活性化合物的(3S)-3-(4-氯-3-{[(2S,3R)-2-(4-氯苯基)-4,4,4-三氟-3-甲基丁醯基]胺基}苯基)-3-環丙基丙酸及其結晶型之方法农业专利-农业专业知识服务系统

发明人:: FEY, PETER,飞　彼特,飛　彼特,RUBENBAUER, PHILIPP,鲁本鲍尔　菲利浦,魯本鮑爾　菲利浦,LOVIS, KAI,拉维斯　凯,拉維斯　凱,OLENIK, BRITTA,欧兰尼克　布列塔,歐蘭尼克　布列塔,KUESEL, JULIA,库塞尔　茱丽亚,庫塞爾　茱麗亞,SPINDLER, FELIX,斯宾德勒　费利克斯,斯賓德勒　費利克斯

摘要：: The present invention relates to a novel and improved process for preparing (3S)-3-(4-chloro-3-{[(2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methylbutanoyl]amino}phenyl)-3-cyclopropylpropanoic acid of the formula (I), to the compound of the formula (I) in crystalline form and to their use for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of cardiovascular, cardiopulmonary and cardiorenal disorders.本發明係關於一種新穎且改良方法，用於製備式(I)的(3S)-3-(4-氯-3-{[(2S,3R)-2-(4-氯苯基)-4,4,4-三氟-3-甲基丁醯基]胺基}苯基)-3-環丙基丙酸、在結晶型的式(I)化合物及其用於治療及/或預防疾病的用途，特別是用於治療及/或預防心血管、心肺和心腎疾病。