Patent No. 601647 Disclosed is an isolated oligopeptide comprising an amino acid sequences such as MITLDDMEEMDGLSDFTG, QLTKQRLVDADGIINPSA, RVGKIRLVDASGIINSDG and so on, wherein said oligopeptide binds a Hedgehog polypeptide and wherein said oligopeptide does not comprise one or both of a frizzled domain and an EGF2 domain.