Jed L. Hubbs;Thomas Miller;Karin M. Otte;David Witter;Jonathan B. Grimm;Phieng Siliphaivanh;Kevin Wilson;Hua Zhou;Matthew G. Stanton
发明人:
Jonathan B. Grimm,Jed L. Hubbs,Thomas Miller,Karin M. Otte,Phieng Siliphaivanh,Matthew G. Stanton,Kevin Wilson,David Witter,Hua Zhou
申请号：
US12224466
公开号：
US08168658B2
申请日:
2007.02.23
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The present invention relates to a novel class of compounds. These compounds can inhibit histone deacetylase and are suitable for use in selectively inducing terminal differentiation, and arresting cell growth and/or apoptosis of neoplastic cells, thereby inhibiting proliferation of such cells. Thus, the compounds of the present invention are useful in treating a patient having a tumor characterized by proliferation of neoplastic cells. The compounds of the invention may also be useful in the prevention and treatment of TRX-mediated diseases, such as autoimmune, allergic and inflammatory diseases, and in the prevention and/or treatment of diseases of the central nervous system (CNS), such as neurodegenerative diseases. The present invention further provides pharmaceutical compositions comprising the compounds of the instant invention and safe dosing regimens of these pharmaceutical compositions, which are easy to follow, and which result in a therapeutically effective amount of these compounds in vivo.
