ПЬЕР Джеральд Б. (US),САЙВЕС-БЕНТЛИ Колетт (US),СКАРНИК Дэвид (US)
申请号：
RU2014152261
公开号：
RU2014152261A
申请日:
2013.05.30
申请国别(地区):
RU
年份:
2016
代理人:
摘要：
1. A method comprising administering to an individual suffering or at risk of developing an ica / pga-free PNAG-positive pathogen effective for inducing an immune response against a pathogen, the amount of an isolated polysaccharide having a formula of at least 5, R is selected from the group consisting of from —NH — CO — CH and —NH, provided that less than 50% of the R groups are —NH — CO — CH. 2. A method comprising administering to an individual suffering or at risk of developing an ica / pga-free PNAG-positive pathogen that is effective for inducing an immune response against the pathogen, the amount of isolated polysaccharide conjugated to a carrier, where the polysaccharide has the formula, where n is 5 or more, R is selected from the group consisting of -NH-CO-CHi -NH, provided that less than 50% of the R groups are -NH-CO-CH.3. The method of claim 2, wherein the isolated polysaccharide is conjugated to the carrier via a linker. The method of claim 2 or 3, wherein the carrier is a peptide carrier. The method of claim 1 or 2, wherein less than 30%, less than 20%, less than 10%, or less than 5% of the R groups are —NH — CO — CH. The method of claim 1 or 2, wherein none of the R groups is —NH — CO — CH. 7. The method of claim 1 or 2, wherein n is at least 15, at least 20, at least 50, at least 100, at least 200, at least 300, at least 400, or at least 500.8 . The method according to claim 1 or 2, where the molecular weight of the selected polysaccharide is 100-500 kDa. The method of claim 1 or 2, wherein the ica / pga-free PNAG-positive pathogen is an ica / pga-free PNAG-positive gram-positive cocc. The method of claim 9, wherein the ica / pga-free PNAG-positive gram-positive coccus is S. pneumonia, Streptococcus group A, Streptococcus group B or Enterococcus. 11. The method of claim 1 or 2, wherein the ica / pga free PNAG positive pathogen is an ica / pga free PNAG positive1. Способ, включающий введение индивидууму, страдающему или подвергающемуся риску развити
