the invention relates to the use of a compound of formula (i) in which x represents o, s, so or so2； r1 is halogen or a group trihalog u00c9nom u00c9thyle, oh, alkyl, alkoxy, cl -, c1 - 4 trifluorom u00c9thoxy, ph u00c9noxy, cyclohexylm u00c9thyloxy, pyridylm u00c9thoxy, cinnamyloxy, naphtylm ph u00c9noxym u00c9thyle (- ch2 -,,, - ch2-ch2 - alkylsulfinyle c1-4 alkylthio, c1 - 4 alkylsulfonyle c1 - 4ac u00c9tyle benzylthio, nitro or cyano group, or a phenyl, alkyl ph u00c9nyle, (4) or (c1-4 alkoxy, phenyl), each group ph u00c9nyle is eventually substitu u00c9 by halogen or alkyl group, cf3, c1-4 alkoxy, r2 is c1 - 4 h, a halogen, or a group trihalog u00c9nom alkoxy ethyl, c1-4 alkyl, c1 -, ph u00c9nyl u00c9thyle or benzyloxy； r3 represents h,a halogen or cf3, oh, alkyl, c1 -, alkoxy, c1-4, benzyloxy, ph u00c9nyle or c1-4 alkoxy methyl)； each of r4 and r5 represents independently h or waste of formula (a) wherein each of r8 and r9 is, independently.h or an alkyl group, c1-4, eventually substitu u00c9 by halogen； and n represents an integer of 1 to 4； or a pharmaceutically acceptable salt, solvate, hydrate, or prom u00c9dicament, isomer thereof or a compound of formula ii wherein r1a is halogen or a group trihalog u00c9nom u00c9thyle group, alkyl c1-4 alkoxy, alkylthio, c1-4, c1 - 4 alkylsulfinyle c1 - 4alkylsulfonyle aralkyle, c1-4, ph u00c9noxy eventually substitu u00c9 aralkyloxy r2a is h, or halogen； or a group trihalog u00c9nom u00c9thyle, c1-4 alkoxy, alkyl, c1 - 4 aralkyle aralkyloxy r3a is h, or halogen； or a group cf3, c1-4 alkoxy, alkyl, c1 - 4 alkylth oi, c1-4 or benzyloxy； r4a is h or an alkyl group of c1 - 4 ph u00c9nyle.benzyl or benzoyl, and eventually substitu u00c9 lower aliphatic acyl； (5)； r5a represents h or an alkyl group monohalog u00c9nom u00c9thyle, c1-4, c1-4 alkoxy methyl, alkyl), c1 - 4) thiom u00c9thyle, hydroxym u00c9thyle, aralkyle, alc u00c9nyle ph u00c9nyle, polydimethylsiloxane, c2-4, or alcynyle in c2 - 4； a6a is h or an alkyl group, c
