RATCLIFFE, PETER,MAXWELL, PATRICK,PUGH, CHRISTOPHER
申请号：
AT00929704
公开号：
AT552270T
申请日:
2000.05.12
申请国别(地区):
AT
年份:
2012
代理人:
摘要：
The invention relates to the finding that the VHL tumour suppressor protein regulates hypoxia inducible factor &alpha； subunits, by targeting HIF &alpha； for destruction in normoxic, but not hypoxic cells. The invention provides assays for modulators of this interaction, and peptides based upon HIF &alpha； subunit sequences which may modulate this interaction.
