ANDREA RIZZI,ROBERT ANDREW HEALD,JONATHAN MARK SUTTON,CARMELIDA CAPALDI,ELISABETTA ARMANI
申请号：
ARP150104032
公开号：
AR102967A1
申请日:
2015.12.10
申请国别(地区):
AR
年份:
2017
代理人:
摘要：
1. Property 1: a compound with the property of common formula (1), wherein a is - cho-n；B is - CH o-n；D is -CH O-N.X is -CH O-N.R3 is - cf8323；a. Chf832222 or halogen； W is a heteromorphic ring with 5 or 6 members, which can be replaced by one or more substitutes selected from - CN, - no.832222；-OC₁₋₆ alkyl, -C₁₋₃ alkyl-O-C₁₋₆ alkyl, -C₁₋₃ alkylamino, -C₃₋₈ cycloalkyl, -OH, C₁₋₃ alkyl, halo, -CF₃ and -SO₂C₁₋₄ alkyl； R¹ is H or is selected from the group consisting of -C (O) R⁴,- (CH) - (CHR) -R- (CH) - (CHR) S (O) -NR R-S (O) -R- (CH) - (CHR) -C (O) -NR R- (CH) - (CHR) -C (O) O-RR⁴ is H or is selected from the group consisting of -C₁₋₆ alkyl, -C₂₋₆ alkyl-NR⁷R⁸,-C₂₋₆ alkyl-N⁺R⁷R⁸R⁹,-C833228331 local No. 8326-o-c8321； cycloquilo Y - (ch8322) - 834883； - heterogeneous, optionally replaced by one or more alternatives selected from - CN, - No. 832222；-OC₁₋₆ alkyl, -C₁₋₃ alkyl-O-C₁₋₆ alkyl, -C₁₋₃ alkylamino, -C₃₋₈ cycloalkyl, -OH, C₁₋₃ alkyl, halo, -CF₃ and -SO₂C₁₋₄ alkyl； n is 0 or an integer selected from 1, 2 or 3； t is 0 or an integer selected from 1, 2 or 3； R⁵ is H or -C₁₋₆ alkyl； R⁶ is H, -C₁₋₆ alkyl, -CF₃ or -CHF₂；R⁷ is H or -C₁₋₆ alkyl； R⁸ is H or -C₁₋₆ alkyl； R⁹ is H or -C₁₋₆ alkyl； where alternatively R⁴ and R⁵ together with it nitrogen atom to which they are attached can form a C₃₋₈ heterocycloalkyl or heteroaryl ring system, optionally substituted with one or more substituents selected from -CN, -NO₂,-OC₁₋₆ alkyl, -C₁₋₃ alkyl-O-C₁₋₆ alkyl, -C₁₋₃ alkylamino, -C₃₋₈ cycloalkyl, -OH, C₁₋₃ alkyl, halo, -CF₃ and -SO₂C₁₋₄ alkyl, where the heteroatoms of the C₃₋₈ heterocycloalkyl or heteroaryl ring system are a maximum of three and are selected from -N, -NH, -O, -S- and -SO₂；R2 is h, or selected from the group consisting of, - SME, - S (o) r8311；-S (o832211) r8311 and halogens； and salts acceptable from drugs；Reivindicación 1: Un compuesto caracterizado porque es de fórmula general (1) donde A es -CH o -N-； B es -CH o -N-； D es -CH o -N-； X es -CH o -N-； R³ es -CF₃
