The present invention relates to a method of manufacturing spray-dried powders. During the process, a solvent is used. The process is done in multiple steps such that the emulsification mass ratio is low when removal of the solvent is started. Preferred solvents are isopropyl acetate and ethyl acetate. The invention also relates to a set-up to run the inventive process at industrial scale.本發明係關於一種製造噴霧乾燥粉末之方法。在該方法期間,使用一溶劑。該方法以多個步驟進行,使得當開始移除該溶劑時乳化質量比低。較佳溶劑為乙酸異丙酯及乙酸乙酯。本發明亦係關於一種在工業規模下執行本發明方法之設置。