SIRNA THERAPEUTICS, INC.;Laura Sepp-Lorenzino;Vasant Jadhav;Duncan Brown
发明人:
Marija Tadin-Strapps,Tayeba Khan,Walter Richard Strapps,Laura Sepp-Lorenzino,Vasant Jadhav,Duncan Brown
申请号：
US15035950
公开号：
US10004814B2
申请日:
2014.11.10
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The present invention provides methods comprising the in vivo delivery of small nucleic acid molecules capable of mediating RNA interference and reducing the expression of myostatin, wherein the small nucleic acid molecules are introduced to a subject by systemic administration. Specifically, the invention relates to methods comprising the in vivo delivery of short interfering nucleic acid (siNA) molecules that target a myostatin gene expressed by a subject, wherein the siNA molecule is conjugated to a lipophilic moiety, such as cholesterol. The myostatin siNA conjugates that are delivered as per the methods disclosed are useful to modulate the in vivo expression of myostatin, increase muscle mass and/or enhance muscle performance. Use of the disclosed methods is further indicated for treating musculoskeletal diseases or disorders and/or diseases or disorders that result in conditions in which muscle is adversely affected.
