The present invention discloses an aminopyrimidine fused five-membered heterocyclic compound as shown in Formula I, an intermediate thereof, a manufacturing method, a pharmaceutical composition, and an application thereof. The aminopyrimidine fused five-membered heterocyclic compound of the present invention has an obvious antagonistic action on an adenosine A2A receptor, and can be used as an adenosine A2A receptor antagonist, alleviate or treat immune tolerance, central nervous system diseases and inflammation, and other related diseases effectively.本發明公開了一種如式I所示的氨基嘧啶并五元雜環化合物、其中間體、製備方法、藥物組合物及應用。本發明提供的氨基嘧啶并五元雜環化合物對腺苷A2A受體具有明顯的拮抗作用，其可作為腺苷A2A受體拮抗劑，有效緩解或治療免疫耐受、中樞神經系統疾病和炎症性疾病等相關疾病。
