Robert A. Mitchell,John O. Trent,Pooran Chand,Gilles Hugues Tapolsky
申请号：
US13498036
公开号：
US09162987B2
申请日:
2010.09.24
申请国别(地区):
US
年份:
2015
代理人:
摘要：
Compounds useful for the inhibition of macrophage migration inhibitory factor (MIF) are provided herein, having the Formula (I): wherein A is selected from the group consisting of aromatic or non-aromatic rings, bicyclic rings, polycyclic rings, alkenes or alkynes B is H, OH, OR, SR, NH2, NHR, or alkyl R is H or alkyl, and X and Y are independently N or CH, but one of X and Y must be N. Also provided are pharmaceutical compositions comprising a Formula I compound and methods for the treatment of MIF-implicated diseases or conditions, comprising administering a safe and effective amount of a Formula I compound.
