Murphy, Andrew J.,Thurston, Gavin,Varghese, Bindu,Gurer, Cagen
申请号：
HRP20190227
公开号：
HRP20190227T1
申请日:
2019.02.05
申请国别(地区):
HR
年份:
2019
代理人:
摘要：
Genetically modified non-human animals and methods and compositions for making and using the same are provided, wherein the genetic modification comprises a humanization of an endogenous signal-regulatory protein gene, in particular a humanization of a SIRP± gene. Genetically modified mice are described, including mice that express a human or humanized SIRP± protein from an endogenous SIRP± locus.
