A nanoparticle-containing composition for highly efficient skin brightening, whitening, moisturizing is prepared by mixing noble metal, such as platinum, gold, palladium and silver, nanoparticles, zinc oxide nanoparticles, tranexamic acid powder, a dispersant, deionized water and gelatin or a cream in predetermined weight percentages. An aqueous solution of the noble metal nanoparticles is mixed with an aqueous solution of the zinc oxide nanoparticles to produce a primary mixed solution, whose clear upper-layer liquid is extracted and added with the deionized water to produce a secondary mixed solution. The secondary mixed solution is added with the tranexamic acid powder and the dispersant to produce a final mixed solution, whose clear upper-layer liquid is extracted, added with the gelatin or cream and thoroughly stirred until the desired consistency is reached.