The present invention provides a tissue closure device, comprising: a first clamping base and a second clamping base which may be opened/closed relatively and form an accommodation cavity after being closed； and a pouch assembly which may be driven to move from a proximal end to a distal end in the accommodation cavity, wherein: the pouch assembly comprises a staple pusher, a pair of needle heads movably connected to the staple pusher, and a connection portion connected to the proximal ends of the pair of needle heads； and when the staple pusher moves from the proximal end to the distal end, the pair of needle heads pushes a tubular tissue located in the accommodation cavity to the distal end until the distal ends of the pair of needle heads are closed to close the tubular tissue into a purse string. A bundled purse string with a gathered center may be formed through the tissue closure device.
