Provided are taxanes compounds having the structure of formula I, preparation method thereof, and uses of compositions having the compound, pharmaceutical salts and solvates thereof as active ingredients in the preparation of oral antitumor drugs. In the formula, R 1 is -COR 6 , -COOR 6 , and -CONR 7a R 7b ； R 2 is C1-C6 alkyl, C1-C6 alkenyl group, a substituted hydrocarbon group, a heterocyclic group, an aromatic group or a substituted aromatic group； R 3 is -OR 6 ,-OCOOR 6 , -OCOSR 6 , and -OCONR 7a R 7b ； R 4 is -OR 6 , -OCOOR 6 , -OCOSR 6 , -OCONR 7a R 7b , H, and OH； R 6 is C1-C6 alkyl, C1-C6 alkenyl, C1-C6 alkynyl group, a substituted hydrocarbon group, an aromatic group or a heterocyclic group； and R 7a and R 7b are respectively hydrogen, a hydrocarbon group, a substituted hydrocarbon group or a heterocyclic group.
