THE UNITED STATES OF AMERICA; AS REPRESENTED BY THE SECRETARY; DEPARTMENT OF HEALTH AND HUMAN SERVICES
发明人:
Peter L. Collins,Cindy L. Luongo,Ursula J. Buchholz,Brian R. Murphy
申请号：
US14394226
公开号：
US09624475B2
申请日:
2013.03.13
申请国别(地区):
US
年份:
2017
代理人:
摘要：
Provided herein are recombinant respiratory syncytial viruses that contain mutations that make the disclosed viruses attractive vaccine candidates. The viruses disclosed contain attenuating mutations designed to have increased genetic and phenotypic stability. Desired combinations of these mutations can be made to achieve desired levels of attenation. Exemplary vaccine candidates are described. Also provided are polynucleotides capable of encoding the described viruses, as wells as methods for producing the viruses and methods of use.
