The syringe (1) has a stopper arranged within a body (2) such that a front surface of the stopper and the body define a variable volume chamber from which a fluid is expelled though an outlet of the body, and a backstop (6) including two finger projections. A plunger (4) comprises a plunger contact surface to contact the stopper such that the plunger forces the stopper towards an outlet end. The syringe is filled with a vascular endothelial growth factor (VEGF) antagonist fluid of about 0.15-0.175 ml containing a non-antibody VEGF antagonist aflibercept at a concentration of 40 mg/ml. The syringe comprises a syringe barrel filled with silicone oil of 100 microgram.
