HIGHLY EFFICIENT NRF2 ACTIVATORS-CO-RELEASING MOLECULE HYBRIDS, THEIR USE IN THE TREATMENT OF INFLAMMATORY OR CARDIOVASCULAR DISEASES AND THEIR PROCESS OF PREPARATION

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专利权人:

Centre National de la Recherche Scientifique;Universite Paris est Creteil val de Marne;Institute National de la Sante et de la Researche Medicale

发明人:

Roberto MOTTERLINI,Roberta Foresti,Anthony Ollivier,Michael Rivard,Thierry Martens

申请号：

US15762488

公开号：

US20180258121A1

申请日:

2016.09.23

申请国别(地区):

US

年份:

2018

代理人:

摘要：

The present invention relates to highly efficient Nrf2 activators-CO-releasing molecules of formula (I) and (II) capable of increasing HO-1 protein expression and simultaneously releasing CO, their synthesis and their use in therapeutic applications, in particular their use in the treatment of inflammatory or cardiovascular diseases, wherein CORM represents a carbonyl metal complex chosen from among: Mn(CO)5, formula (III), (IV), (V), (VI), (VII), (VIII) and (IX).

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