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CARBAMATE DERIVATIVES OF ALKYL-HETEROCYCLES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF
专利权人:
SANOFI;САНОФИ
发明人:
Ahmed,Ахмед,Nathalie,Натали,Aude,Од,Mourad,Мурад,Julien,Жюльен,Corinne,Коринн,Philippe,Филипп
申请号:
EA201170686
公开号:
EA019742B1
申请日:
2009.11.13
申请国别(地区):
EA
年份:
2014
代理人:
摘要:
Compound corresponding to general formula (I), in which R2 represents a hydrogen or fluorine atom or a hydroxyl, C1-6-alkyl or NR8R9 group; n represents an integer equal to 1, 2 or 3 and m represents an integer equal to 1 or 2; A represents a covalent bond or a C1-8-alkylene group; R1 represents a group R5 optionally substituted with one or more groups R6 and/or R7; R5 represents a group chosen from phenyl, pyridinyl, pyridazinyl, pyrimidinyl, pyrazinyl, quinolinyl, isoquinolinyl, phthalazinyl and quinoxalinyl; R6 represents a halogen atom, a nitro group, C1-6-alkyl, C1-6-alkoxy, C1-6-haloalkyl, C1-6-haloalkoxy or -O-(C1-3-alkylene)-O- group; R7 represents phenyl possibly being substituted with one or more groups R6 that may be identical to or different from each other; R3 represents a trifluoromethyl group, a group C1-6-alkyl or a hydrogen atom; R4 represents a group chosen from furanyl, oxazolyl, isoxazolyl, pyrazolyl, oxadiazolyl, thiadiazolyl, imidazolyl and triazolyl; this group being optionally substituted with one or more substituents chosen from a group C1-6-alkyl, CO2R8, CONR8R9, CON(R8)(C1-3-alkylene-NR10R11) and phenyl; wherein phenyl possibly being substituted with one or more substituents chosen from a halogen atom and C1-6-alkoxy; R8, R9, R10 and R11 represent, independently of each other, a hydrogen atom or a group C1-6-alkyl, or form, with the atom(s) that bear(s) them, in the case of NR8R9, a piperazine ring, this ring being optionally substituted with a group C1-6-alkyl; in the form of base or of an acid-addition salt; to the therapeutic use thereof.Изобретение относится к соединению, отвечающему общей формуле (I), в которой R2 означает атом водорода или фтора либо гидроксил, C1-6-алкил или группу NR8R9; n означает целое число, равное 1, 2 или 3, и m означает целое число, равное 1 или 2; А означает ковалентную связь или C1-8-алкиленовую группу; R1 означает группу R5, необязательно замещенную одной или несколькими группами R6 и/или R7; R5 означает г
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