The present invention relates to the use of piperphentonamine or pharmaceutically acceptable salts thereof in manufacture a medicine for preventing/treating encephalopathy in mammal, and a use of combination of piperphentonamine or pharmaceutically acceptable salts thereof and other medicine in manufacture a medicine for preventing/treating encephalopathy in mammal. The mammal includes human, the encephalopathy including cerebral injury disease or cerebrovascular disease. The cerebrovascular disease refers to cerebral ischemia, cerebral ischemia / reperfusion injury or cerebral hemorrhage. The cerebral hemorrhage includes: hypertensive cerebral hemorrhage, cerebral hemorrhage secondary to infarction, tumor cerebral hemorrhage or cerebral hemorrhage caused by arteritis. The cerebral ischemia include: carotid system cerebral ischemia or vertebrobasilar cerebral ischemia.
