Compositions and therapeutic uses of HEPES and derivatives in the treatment of pain associated with cancers and side-effects including post-chemotherapy cognitive impairment are disclosed herein. HEPES is also used to treat neurodegenerative and neurological diseases, demyelinization injuries, and side-effects and withdrawal symptoms associated with benzodiazepines, anti-depressants, and other neurological agents.本發明揭示HEPES及衍生物之組合物及治療用途，用於治療與癌症相關之疼痛及副作用，包括化學療法後認知受損。HEPES亦用於治療神經退化性疾病及神經疾病，髓鞘損失損傷，及與苯并二氮呯、抗抑鬱藥、及其他神經藥物相關之副作用及停藥症狀。
