The present invention provides a non parenteral and non ocular herbal synergistic detoxifier composition effective for blood purification, blood detoxification and in the treatment and management of disorders related to accumulation of toxins in the body. The present invention also provided a method of preparation of this formulation. In a preferred embodiment, the composition comprises Echinacea purpurea leaves, Andrographis paniculata leaves, Boerhaavia diffusa whole plant, Arctium lappa root, Rubia cordifolia root effective amount of one or more bio - availability enhancer. The bio - availability enhancer may be of herbal origin or chemical origin. The bio - availability enhancer of herbal origin may selected from the group includingextract or powder of Berberis aristata stem and Tinospora cordifolia stem. The bio - availability enhancer of chemical origin may be selected from the group including gluceryl mono oleate, poly vinyl alcohol, Span 80, Tween 80, Tween 20 and PEG 200 to PEG 6000 or a combination thereof. The composition may further contain Pothos aureus, leaves of Ixora coccinea, stems of Jacaranda mimosifolia, roots of Hemidesmus indicus, heartwood of Acacia catechu, stem of Cassia biflorain, leaf of Cassia seamia and flower of Dahlia pinnata.
