A system and method for programming customized data collection for an autonomous medical device is presented. Data measures to be recorded by an autonomous medical device with remote monitoring are dynamically identified to evaluate a patient status. One or more operational parameters for the autonomous medical device that specify collection of the data measures are defined. A data source to measure each data measure is identified. Collection conditions applicable to the data source are specified. Resources allocated to transiently stage the data measure in the autonomous medical device are managed. The operational parameters are programmed to effect functional changes in the collection of the data measures to the autonomous medical device. The autonomous medical device is regularly interrogated to remotely retrieve the data measures recorded under the operational parameters.