JOSEPH MARIA GERARDUS BARBARA CALS,SANDER BERNARDUS NABUURS,VERA DE KIMPE,VERA D
申请号：
BR112017026231
公开号：
BR112017026231A2
申请日:
2016.06.03
申请国别(地区):
BR
年份:
2018
代理人:
摘要：
ror gamma modulators (rory)? The present invention relates to compounds according to formula I: (formula i) or a pharmaceutically acceptable salt thereof, wherein - a1-a8 are n or cr1-cr8, respectively, with the provision that not more than two of four positions a at a1-a4 can be simultaneously n and no more than two of the four positions a at a5-a8 can be simultaneously n； R1 -8 is independently h, halogen, amino, c (1-3) alkoxy, (di) c (13) alkylamino or c (16) alkyl； R9 is c (1-6) alkyl； R10 and R11 are independently h, f, methyl, ethyl, hydroxy or methoxy or R10 and R11 together are carbonyl, all alkyl groups, if present, optionally substituted by one or more f； R12 is h or c (1-6) alkyl； R13 is c (3-6) cycloalkyl, c (36) cycloalkyl (13) alkyl, c (2-5) heterocycloalkyl, c (25) heterocycloalkyl (1-3) alkyl, c (6-10) aryl, c (6-10) aryl (1-3) alkyl, c (19) heteroaryl or c (1-9) heteroaryl (1-3) alkyl； R14 is h, c (1-6) alkyl, c (2-6) alkenyl, c (3-6) cycloalkyl, c (36) cycloalkyl (13) alkyl, c (25) heterocycloalkyl, c ( 2-5) heterocycloalkyl (1-3) alkyl, c (6-10) aryl, c (6 10) aryl (1-3) alkyl, c (1-9) heteroaryl or c (1-9) heteroaryl (1 -3) alkyl； - or r13 and r14 are fused to form a ring having 5 to 7 atoms joining r13 which is c (1-6) alkyl or c (2-6) alkenyl with an independent substitutable within the definition of r14, all groups optionally substituted by one or more halogen, amino, hydroxy, cyano, c (13) alkoxy, c (13) alkoxycarbonyl, (di) and (13) alkylamino or c (13) alkyl. The compounds may be used as rory inhibitors and are useful for the treatment of rory mediated diseases.?moduladores de ror gama (rory)? a presente invenção se refere a compostos de acordo com a fórmula i: (fórmula i) ou um sal farmaceuticamente aceitável deste, em que - a1-a8 são n ou cr1-cr8, respectivamente, com a provisão de que não mais de duas das quatro posições a em a1-a4 possam ser simultaneamente n e que não mais que duas das quatro posições a em a5-a8 possa ser simultaneame
