A surgical spray instrument (1) is disclosed comprising a main body (2) connectable to a transfer tube (3) a propellant actuator (7) for selectively releasing propellant (4) from the main body and along the transfer tube and out through a distal end (3b) thereof. An ion emitter (8) is arranged along the tube, the ion emitter having an ion emission zone (9). This enables the directed and concentrated delivery of therapeutic, pharmacological and diagnostic agents to tissues inside or outside of the body.
