The present invention is directed to a transdermal delivery device comprising ketamine and formulations thereof. The present invention is also directed to a transdermal delivery device comprising ketamine for the treatment of major depressive disorder (MDD) and / or pain. The present invention is further directed to a transdermal delivery device comprising ketamine and an abuse deterrent agent.本発明は、ケタミン及びその製剤を含む経皮送達デバイスを対象とする。本発明はまた、大うつ病性障害(MDD)及び/又は痛みの治療用のケタミンを含む経皮送達デバイスを対象とする。本発明はさらに、ケタミン及び乱用抑止剤を含む経皮送達デバイスを対象とする。