Systems and methods for sensing bubbles during fluid infusion are disclosed. An infusion device comprises a pathway, a pump adjacent the pathway, one or more bubble sensors, and first and second modules. The pump alters the pathway to pump fluid through tubing received in the pathway. The bubble sensors are configured to detect bubbles in the fluid being pumped through the tubing. The first module is configured to generate a first alarm condition when the bubble sensors detect a bubble having a first volume above a first preselected threshold. The second module is configured to generate a second alarm condition when the bubble sensors detect a plurality of bubbles over a preselected period of time having a combined volume above a second preselected threshold. A third module may be also be used to record a total combined volume of bubbles detected by the bubble sensors during an infusion event.
