SYNTHEIS OF NOVEL (4E)-4-(4-SUBSTITUTED BENZYLIDENEAMINO)-2,3-DIHYDRO-3-SUBSTITUTED -2 THIOXOTHIAZOLE-5-CARBONITRILE AS NOVEL ANTAGONISTS AND PROCESS FOR PREPARATION THEREOF
The present invention relates to novel synthesis of 4E)-4-(4-substituted benzy1ideneamino)- 2,3-dihydro-3-substituted -2-thioxothiazole-Scarbonitriles of general formula 2 wherein R and R1 are selected from a group consisting of wherein R is selected from a group consisting of hydrogen, alkyl (having carbon no up to 10 etc.), cycloalkyl, aromatic, substituted aromatics (halogen, OH, COOH, OCH3, alkyl, etc), substituted heterocyclics including heteroaromatics compounds ( upto seven member). R1 is selected from a group consisting of halides, 0 (hydrogen, alkyl (having carbon no up to 10 etc.), cycloalkyl, aromatic, substituted aromatics (halogen, OH, COOH, OCH3, alkyl, etc), substituted heterocyclics including heteroaromatics compounds ( upto seven member), S hydrogen, alkyl (having carbon no up to 10 etc.), cycloalkyl, aromatic, substituted aromatics (halogen, OH, COOH, OCH3, alkyl, etc), substituted heterocyclics including heteroaromatics compounds ( upto seven member) , COO (hydrogen, alkyl (having carbon no up to 10 etc.), cycloalkyl, aromatic, substituted aromatics (halogen, OH, COOH, OCH3, alkyl, etc), substituted heterocyclics including heteroaromatics compounds (upto seven member), NR2R3 (hydrogen, alkyl (having carbon no up to 10 etc.), cycloalkyl, aromatic, substituted aromatics (halogen, OH, COOH, OCH3, alkyl, etc), substituted heterocyclics including heteroaromatics compounds ( upto seven member) and substituted amino, and alkyl (up to five carbon chain). Present invention disclosed general formula 1 having R is ethyl, propyl, butyl ally1 as well as phenyl. Particularly the present invention relates to )-4-(4-substituted benzylideneamin0)-2,3- dihydro-3-substituted -2-thioxothiazole-5-carbonitriles. The compounds of present invention are usefhl in the treatment of central nervous disorders including, Parkinson disease, Huntington"s disease, attention disorder, cognition, Alzheimer disease, depression and hypertension.
