PROTEINES MONOSPECIFIQUES ET BISPECIFIQUES A ROLE DE REGULATION DE POINTS DE CONTROLE IMMUNITAIRE DESTINEES AU TRAITEMENT DU CANCER

• 收藏
• 分享

专利权人:

INC.;AP BIOSCIENCES

发明人:

HER, JENG-HORNG,YOU, JHONG-JHE,HSU, CHING-HSUAN,HUANG, PO-LIN,KAN, HUNG-TSAI,CHANG, TING-YI,HSIEH, HSIN-TA

申请号：

CA3082036

公开号：

CA3082036A1

申请日:

2018.12.28

申请国别(地区):

CA

年份:

2019

代理人:

摘要：

Provided are monospecific and bispecific proteins that bind specifically to OX40 and/or PD-L1. Exemplary proteins release the inhibition through PD-L1 and stimulate T cell through OX40. Exemplary polyvalent proteins comprise at least one OX40 binding site and at least one PD-L1 binding site. In certain embodiments, the binding sites may be linked through an immunoglobulin constant region. Anti-OX40 and anti-PD-L1 antibodies are also provided.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/