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PROTEINES MONOSPECIFIQUES ET BISPECIFIQUES A ROLE DE REGULATION DE POINTS DE CONTROLE IMMUNITAIRE DESTINEES AU TRAITEMENT DU CANCER
专利权人:
INC.;AP BIOSCIENCES
发明人:
HER, JENG-HORNG,YOU, JHONG-JHE,HSU, CHING-HSUAN,HUANG, PO-LIN,KAN, HUNG-TSAI,CHANG, TING-YI,HSIEH, HSIN-TA
申请号:
CA3082036
公开号:
CA3082036A1
申请日:
2018.12.28
申请国别(地区):
CA
年份:
2019
代理人:
摘要:
Provided are monospecific and bispecific proteins that bind specifically to OX40 and/or PD-L1. Exemplary proteins release the inhibition through PD-L1 and stimulate T cell through OX40. Exemplary polyvalent proteins comprise at least one OX40 binding site and at least one PD-L1 binding site. In certain embodiments, the binding sites may be linked through an immunoglobulin constant region. Anti-OX40 and anti-PD-L1 antibodies are also provided.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/
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