ABT Holding Company;Board of Regents of the University of Texas System
发明人:
Charles Samuel COX,Robert W. Mays
申请号：
US15064180
公开号：
US20180311287A9
申请日:
2016.03.08
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The invention provides methods for treating traumatic brain injury. The invention is generally directed to treating traumatic brain injury by administering cells that have one or more of the following effects in an injured subject: interact with splenocytes, preserve splenic mass, increase proliferation of CD4+ and CD8+ T-cells, increase IL-4 and IL-10, and increase M2:M1 macrophage ratio at the site of injury. The invention is also directed to drug discovery methods to screen for agents that modulate the ability of the cells to have these effects. The invention is also directed to cell banks that can be used to provide cells for administration to a subject, the banks comprising cells having desired potency for achieving these effects.
