This invention provides methods and systems uniquely capable of enhancing medicant delivery and/or effectiveness through the use of energy to predictably disrupt membranes and mechanically and thermally modulate cells and tissues. In exemplary embodiments, the methods and systems disclosed herein are capable of modulating multiple layers of tissue. In an exemplary embodiment, the energy is acoustic energy (e. g., ultrasound). In other exemplary embodiments, the energy is photon based energy (e. g., IPL, LED, laser, white light, etc.), or other energy forms, such radio frequency electric current, or various combinations of acoustic energy, electromagnetic energy and other energy forms or energy absorbers such as cooling. Medicants can be first introduced to the region of interest by diffusion, circulation, and/or injeciton. An exemplary system for enhancing medicant delivery and/or effectiveness comprises a control system, a probe, and a display or indicator system. Imaging and/or monitoring may alternatively be coupled and/or co-housed with an ultrasound system contemplated by the present invention.本發明提供獨特地能強化藥劑輸送及/或效能之方法及系統，其透過使用能量以破壞膜並機械地與熱地調整細胞與組織。於例示實施例中，於此揭露之方法及系統能調整組織的多層。於例示實施例中，此能量為聲波能量(例如超音波)。於其他例示實施例中，此能量為光子基能量(例如IPL、LED、雷射、白光等)，或其他能量形式，例如射頻電流，或聲波能量、電磁能、以及其他能量形式或能量吸收器(例如冷卻器)之各種組合。首先藥劑可藉由擴散、循環、及/或注射導入關注區域。強化藥劑輸送及/或效能之系統的範例包含控制系統、探針、以及顯示或指示系統。顯像及/或監測可選替地耦合至本發明所考量之超音波系統，及/或與其共同容置。
