The present disclosure relates generally to symptom management. More specifically, the disclosure describes a system that pairs biomonitoring mechanisms with a symptom management system. In some aspects, the symptom management system may comprise customized programming that may provide engaging user activities that may directly or indirectly affect one or more symptoms. In some embodiments, a user may be diagnosed with a disease, infection, or disorder, and the symptom management system may manage and monitor a predefined set of symptoms associated with the diagnosis. In some implementations, individual symptoms may be identified and subsequently monitored and managed separately, such as through the creation and subsequent tracking of a symptom management score.