LINDEMANN CHRISTOPHER M.,FRY DAVID SHANK,PREIGH MICHAEL,BLOOM COREY JAY,CRAIG CHRISTOPHER DONOVAN,DUBOSE DEVON BREVARD,GAUTSCHI JEFF,SMITHEY DAN
申请号：
NZ62494212
公开号：
NZ624942A
申请日:
2012.10.12
申请国别(地区):
NZ
年份:
2016
代理人:
摘要：
Disclosed is a solid dispersion of the selective ErbB2 (HER2) inhibitor N4-(4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)-3-methylphenyl)-N6-(4,4-dimethyl-4,5-dihydrooxazol-2-yl)quinazoline-4,6-diamine (ARRY -380) and processes for preparing the solid dispersion. Also disclosed are pharmaceutical compositions comprising a solid dispersion of N4-(4-([1,2,4]triazolo[1,5-&alpha]pyridin-7-yloxy)-3- methylphenyl)-N6-(4,4-dimethyl-4,5-dihydrooxazol-2-yl)quinazoline-4,6-diamine for treating cancer.
