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TREATMENT OF CHORIOIDAL NEOVASCULARIZATION USING VACCINES
专利权人:
ИНК. (JP);ОНКОТЕРАПИ САЙЕНС
发明人:
ЦУДЗИКАВА Мотокадзу (JP),НАКАМУРА Юсуке (JP),ЦУНОДА Такуя (JP)
申请号:
RU2012100241/15
公开号:
RU2012100241A
申请日:
2010.06.10
申请国别(地区):
RU
年份:
2013
代理人:
摘要:
1. A pharmaceutical composition for treating and / or preventing a disease caused by neovascularization of human choroid (neovascular maculopathy), containing as an active ingredient at least one type of peptides from (a) peptides containing the amino acid sequence derived from VEGF receptor protein 1, and capable of inducing cytotoxic T cells; and / or a polynucleotide encoding it. 2. The pharmaceutical composition according to claim 1, in which the above peptides according to (a) include the peptide (i) and (ii) described below: (i) at least one peptide containing an amino acid sequence selected from the group consisting of SEQ ID NO : 1-4; (ii) at least one peptide containing an amino acid sequence with one or more amino acid substitutions, divisions, additions and / or inserts in an amino acid sequence selected from the group consisting of SEQ ID NO: 1-4.3. The pharmaceutical composition according to claim 2, in which the above peptide according to (ii) is any one of the peptides (1) to (6) described below: (1) a peptide in which the second amino acid from the N-terminus of any one of the amino acid sequences of SEQ ID NO: 1-3 is a leucine or methionine; (2) a peptide in which the C-terminal amino acid of any one of the amino acid sequences of SEQ ID NO: 1-3 is a valine or leucine; (3) a peptide in which the second amino acid from the N-terminus of any one of the amino acid sequences of SEQ ID NO: 1-3 is leucine and and methionine and C-terminal amino acid is any one of amino acid sequences of SEQ ID NO: 1-3 is valine or leucine, and (4) peptide, wherein the second amino acid from the N-conc1. Фармацевтическая композиция для лечения и/или предупреждения заболевания, вызванного неоваскуляризацией хориоидеи человека (неоваскулярной макулопатией), содержащая в качестве активного ингредиента по меньшей мере один тип пептидов из (а) пептидов, содержащих аминокислотную последовательность, полученную из белка VEGF-рецептора 1, и способных индуцировать цитотоксические Т
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