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Pharmaceutical compositions comprising fatty acid esters
专利权人:
ALKERMES PHARMA IRELAND LIMITED
发明人:
Hickey Magali B.,Perry Jason M.,Remenar Julius F.,Vandiver Jennifer
申请号:
NZ63064313
公开号:
NZ630643A
申请日:
2013.03.13
申请国别(地区):
NZ
年份:
2017
代理人:
摘要:
Disclosed is injectable pharmaceutical compositions comprising: (a) a water-insoluble antipsychotic agent (b) a C1-6 alkyl ester of a C10-20 fatty acid (c) a polyoxy ethylene derivative of a sorbitan ester of a carboxylic acid, wherein the carboxylic acid comprises 8-20 carbon atoms and (d) an aqueous vehicle wherein the composition forms an aqueous, flocculated, injectable suspension. In an embodiment, the fatty acid is ethyl oleate, isopropyl oleate, ethyl myristate, or isopropyl myristate. These compositions are useful for the delivery of anti-psychotic drugs such as aripiprazole and olanzapine.
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