INSTITUTO NACIONAL DE INVESTIGACION Y TECNOLOGIA AGRARIA Y ALIMENTARIA
发明人:
MARTINEZ ESCRIBANO, JOSE ANGEL,WIGDOROVITZ, ANDRES,GIL DONES, FELIX,OSTACHUK, AGUSTIN,PEREZ FILGUERA, MARIANO,DOMINGUEZ, JAVIER,NUNEZ SERRANO, CARMEN,DUS SANTOS, MARIA JOSE,ALONSO MARTI, COVADONGA
申请号：
EP08736740
公开号：
EP2298910A4
申请日:
2008.03.14
申请国别(地区):
EP
年份:
2012
代理人:
摘要：
Fusion protein with directioning of vaccinal antigens toward antigen-presenting cells and the applications thereof. This invention relates to a gene construct that comprises, operatively bound, at least one nucleotide sequence (A) that encodes a polypeptide with SEQ ID NO: 1, which has a region that recognises the ² chain of the class-II DR antigen present on the surface of antigen-presenting cells and one nucleotide sequence (B) that encodes a vaccinal antigen of interest. Moreover, this invention relates to recombinant vectors useful for the expression of the gene construct of the invention, transgenic cells and plants transformed or transfected with said vectors, fusion proteins encoded by the gene construct of the invention and vaccines that comprise said fusion proteins.
