MENET, CHRISTEL JEANNE MARIE,VAN ROMPAEY, LUC JULIAAN CORINA,FLETCHER, STEPHEN ROBERT,BLANC, JAVIER,JOUANNIGOT, NOLWENN,HODGES, ALASTAIR JAMES,SMITS, KOEN KURT
申请号：
PL09781072
公开号：
PL2361251T3
申请日:
2009.07.24
申请国别(地区):
PL
年份:
2014
代理人:
摘要：
A novel [1,2,4]triazolo[1,5-a]pyridine compound is disclosed that has a formula represented by the following: This compound may be prepared as a pharmaceutical composition, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, diseases involving cartilage degradation, bone and/or joint degradation, for example osteoarthritis； and/or conditions involving inflammation or immune responses, such as Crohn's disease, rheumatoid arthritis, psoriasis, allergic airways disease (e.g. asthma, rhinitis), juvenile idiopathic arthritis, colitis, inflammatory bowel diseases, endotoxin-driven disease states (e.g. complications after bypass surgery or chronic endotoxin states contributing to e.g. chronic cardiac failure), diseases involving impairment of cartilage turnover (e.g. diseases involving the anabolic stimulation of chondrocytes), congenital cartilage malformations, diseases associated with hypersecretion of IL6 and transplantation rejection (e.g. organ transplant rejection) and proliferative diseases.
