PROBLEM TO BE SOLVED: To provide compounds that are useful for treating spinal muscular atrophy (SMA).SOLUTION: There are provided 2,4-Diaminoquinazolines of formula (I) that are useful for treating spinal muscular atrophy (SMA). The 2,4-Diaminoquinazolines can be formulated in combination with a therapeutically effective amount of a second drug that improves the SMA and is chosen from histone deacetylase inhibitors and methylase inhibitors.COPYRIGHT: (C)2013,JPO&INPIT【課題】脊髄性筋萎縮症(SMA)の治療に有用な化合物の提供。【解決手段】脊髄性筋萎縮症(SMA)の治療に有用な式(I)の2,4-ジアミノキナゾリン。また治療有効量のSMAを改善するヒストン脱アセチル化酵素阻害剤およびメチル化酵素阻害剤から選択される第2の薬物と併用して処方することもできる。【選択図】なし
