ADENOVIRUS SYNTHETIQUE AVEC TROPISME POUR UN TISSU ENDOMMAGE POUR UTILISATION DANS LA STIMULATION DE LA REPARATION DE PLAIE ET LA REGENERATION TISSULAIRE

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专利权人:

SALK INSTITUTE FOR BIOLOGICAL STUDIES

发明人:

O'SHEA, CLODAGH,POWERS, COLIN,ZHANG, LEI,OSHEA, CLODAGH

申请号：

CA3000462

公开号：

CA3000462A1

申请日:

2016.10.05

申请国别(地区):

CA

年份:

2017

代理人:

摘要：

Synthetic adenoviruses having chimeric fiber proteins and liver detargeting mutations are described. The synthetic adenovirus vectors are capable of specifically infecting cells at wound sites or in regions of damaged tissue. The synthetic adenovirus vectors also are capable of expressing transgenes, such as wound healing factors, at sites of wounded or damaged tissue. Accordingly, the described vectors can be used to detect wounded or damaged tissue, and/or to promote wound healing and regeneration of damaged tissue, such as by expression of heterologous wound healing or tissue regeneration factors.

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中国工程科技知识中心

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http://www.ckcest.cn/home/