Protofibril-binding antibodies and their use in therapeutic and diagnostic methods for parkinsons disease, dementia with lewy bodies and other α-synucleinopathies
Eva Nordström,Alex Kasrayan,Monica Ekberg,Valentina Screpanti Sundquist,Lars Lannfelt,Mats Holmquist
申请号：
US14611690
公开号：
US09084832B2
申请日:
2015.02.02
申请国别(地区):
US
年份:
2015
代理人:
摘要：
In an in vivo method for detecting α-synuclein protofibrils in human tissue, an antibody or fragment thereof is administered to a human. The antibody or fragment is labelled with a detectable label. A complex formed between the antibody or fragment and α-synuclein protofibrils in the human tissue is detected. The antibody or fragment has high affinity for human α-synuclein protofibrils and low affinity for α-synuclein monomers and has a combination of three specified variable heavy (VH) CDR sequences and three specified variable light (VL) CDR sequences.
