Joong-Woong CHO,Gyeong-Hae KIM,Min-Hyo SEO,Sa-Won LEE
申请号：
US15561118
公开号：
US20180125786A1
申请日:
2016.05.27
申请国别(地区):
US
年份:
2018
代理人:
摘要：
Provided are a composition containing an unstable drug against oxidation like pemetrexed with improved stability and a preparation method thereof, by removing oxygen during the preparation. The method is readily applicable for manufacturing by freezing and degassing in a sealed chamber, and can provide formulations with significantly increased stability for the unstable drug against oxidation.
