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ANTAGONISTE DU RÉCEPTEUR MUTÉ DES ANDROGÈNES
专利权人:
Astellas Pharma Inc.
发明人:
申请号:
EP11834469.6
公开号:
EP2631233A1
申请日:
2011.10.21
申请国别(地区):
EP
年份:
2013
代理人:
摘要:
[Problem] An object of the present invention is to provide a novel anticancer drug which is useful for treating prostate cancer accompanying androgen receptor mutation [Means for Solution] The present inventors conducted thorough research on mutant androgen-related diseases for which the traditional anti-androgen drugs become ineffective. As a result, they found that the compound, which is an active ingredient of the pharmaceutical composition of the present invention, exhibits an inhibitory action against transcriptional activation in a human mutant androgen receptor (AR), and has an excellent antitumor action in a human prostate cancer-bearing mouse, thereby completing the present invention. Accordingly, the compound, which is an active ingredient of the pharmaceutical composition of the present invention, is useful for a series of androgen receptor-related diseases including prostate cancer.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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