Disclosed herein is a synthetic PEDF peptide, which has an amino acid sequence that has 20-39 amino acid residues. The synthetic peptide has at least 80% amino acid sequence identity to SEQ ID NO: 1, and includes at least 20 consecutive residues that has at least 90% amino acid sequence identity to residues 11-30 of SEQ ID NO: 1. Also disclosed herein are compositions containing the synthetic peptide and uses thereof. According to various embodiments of the present disclosure, the synthetic peptide is useful in treating osteoarthritis.本說明書揭示一種PEDF合成胜肽,其具有20-39個胺基酸殘基,且其序列與序列編號:1所示之胺基酸序列具有至少80%的胺基酸序列相似度。此合成胜肽有至少20個連續胺基酸殘基,其與序列編號:1所示之第11-30個胺基酸殘基具有至少90%的胺基酸序列相似度。本說明書揭示含有此合成胜肽的組合物及其用途。根據本說明書所載的多種實施方式,此合成胜肽可用以治療骨性關節炎。
