The present invention relates to a non-invasive system and method for glucose monitoring. The said system comprises a glucose monitoring strip and a plurality of portable handheld device. The strip disclosed in the embodiments of the present invention includes a first layer, a second layer and a third layer, wherein the second layer acts as detection layer. To detect the glucose level of a user sample of saliva may be applied to the second layer of strip and may be subjected to the plurality of devices for glucose level calculation. In an embodiments, said devices may be configured to calculate glucose level in different ways, each distinct from other.
