The invention relates to an adenovirus expressing a first protein which is selected among the group comprising an E1B protein and an E4 protein prior to a second protein that is selected among the group comprising an E1A protein, i.e. the order in which adenoviral genes are expressed is reversed. Said virus is used for the production of a medicament or for replication in cells. The inventive medicament is suitable especially for treating tumors that are multiresistant to cytostatic agents.본 발명은 E1B 단백질 및 E4 단백질을 포함하는 군으로부터 선택된 제1 단백질을, E1A 단백질을 포함하는 군으로부터 선택된 제2 단백질 이전에 발현하는 아데노바이러스에 관한 것이다.
