Medical devices, and in particular implantable medical devices, may becoated to minimize or substantially eliminate a biological organism's reactionto theintroduction of the medical device to the organism. The medical devices may becoated with any number of biocompatible materials. Therapeutic drugs, agentsorcompounds may be mixed with the biocompatible materials and affixed to atleasta portion of the medical device. In addition, various polymer combinations maybeutilized to control the elution rates of the therapeutic drugs, agents and/orcompounds from the implantable medical devices. The medical device isdisclosed that comprises an implantable structure, a basecoat matrix and atopcoat. The basecoat matrix includes a combination of rapamycin and acytostatic glucoside, in therapeutic dosages, incorporated in a firstpolymericmaterial. The basecoat matrix is affixed to the surface of the implantablemedicaldevice. The topcoat includes a second polymeric material. The topcoat isaffixedto the basecoat matrix for controlling the elution rate of the rapamycin and acytostatic glucoside.
