BETH ISRAEL DEACONESS MEDICAL CENTER, INC.; INC.;THE BRIGHAM AND WOMEN'S HOSPITAL, INC.;THE BRIGHAM AND WOMENS HOSPITAL
发明人:
Vijay K. Kuchroo,Sumone Chakravarti,Terry Strom,Xin Xiao Zheng,Jennifer Meyers
申请号：
US13750092
公开号：
US20130195895A1
申请日:
2013.01.25
申请国别(地区):
US
年份:
2013
代理人:
摘要：
The invention relates to methods of modulating immune responses in a subject such as by administering to the subject agents which modulate tim-1, tim-2 or tim-4 activity, or which modulate the physical interaction between tim-1 and tim-4 or between tim-2 and a tim-2 ligand. Immune responses include, but are not limited to, autoimmune disorders, transplantation tolerance, and Th1 and Th2-mediated responses and disorders. The invention also relates to novel assays for identifying agents which modulate the physical interaction between tim-1 and tim-4. In addition, the invention relates to novel soluble tim-4 polypeptides and to nucleic acids which encode them.
