WOLF CHARLES ROLAND,WOLF CHARLES ROLAND,SCHEER NICO,SCHEER NICO
申请号：
IN7390/DELNP/2009
公开号：
IN2009DN07390A
申请日:
2009.11.13
申请国别(地区):
IN
年份:
2015
代理人:
摘要：
The present invention relates to transgenic non-human animals, tissues or cells derived therefrom and methods of producing them. The transgenic non-human animals or tissues or cells derived therefrom provide a system capable of expressing human proteins responsible for drug metabolism in place of the homologous endogenous non-human animal proteins and for the controlled expression of human genes introduced into the animal so that the expression of the human genes is regulated in a manner more closely analogous to that seen in vivo in humans. One aspect of the invention relates to the use of a human DNA sequence comprising at least part of introns 6 and/or 7 of the human PXR gene.
