The invention relates to positively charged water-soluble oxicam with a fast skin penetration speed and a prodrug of a related compound of the oxicam. The invention discloses oxicam with an amino capable of being protonized shown in a structural formula I and a derivative of the related compound of the oxicam as well as a pharmaceutical composition and a preparation method of the pharmaceutical composition. The invention further discloses a transdermal treatment application system containing the compound or the pharmaceutical composition of the compound.
