Astellas Pharma Inc.;National University Corporation Tottori University
发明人:
Takafumi Nakamura,Hajime KUROSAKI,Motomu NAKATAKE
申请号：
US16378430
公开号：
US20190336552A1
申请日:
2019.04.08
申请国别(地区):
US
年份:
2019
代理人:
摘要：
The present invention provides a genetically recombinant vaccinia virus effective in preventing or treating cancer. Specifically, the present invention provides a recombinant vaccinia virus lacking functions of VGF and O1L and having a gene encoding B5R in which an SCR domain has been deleted. Specifically, the present invention provides a vaccinia virus comprising two polynucleotides, a polynucleotide encoding IL-7 and a polynucleotide encoding IL-12； a combination kit of two vaccinia viruses, a vaccinia virus comprising a polynucleotide encoding IL-7 and a vaccinia virus comprising a polynucleotide encoding IL-12； and use of the two vaccinia viruses in combination.
